Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
نویسندگان
چکیده
Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases.
منابع مشابه
Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease
The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The ca...
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عنوان ژورنال:
دوره 171 شماره
صفحات -
تاریخ انتشار 2014